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By Gajja S. Salomons, Markus Wyss

This quantity locations emphasis at the problematic interaction among creatine and creatine kinase functionality on one hand and correct mind functionality, neurodegenerative disorder and/or neuroprotection at the different. The publication, compiled via awesome specialists, presents a key reference summarizing the state of the art in creatine and creatine kinase examine. it's a must-read for figuring out the hyperlinks among creatine metabolism and neuroprotection in addition to neurodegenerative disorder.

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Appl. Physiol. 83: 2055–2063. , 2004, Structural and functional adaptations of striated muscles to CK deficiency. Mol. Cell. Biochem. 256–257: 29–41. , 2007, Successful treatment of a guanidinoacetate methyltransferase deficient patient: Findings with relevance to treatment strategy and pathophysiology. Mol. Genet. Metab. 91: 294–296. , 2005, Laboratory diagnosis of defects of creatine biosynthesis and transport. Clin. Chim. Acta 361: 1–9. , 1975, Creatine Kinase Isoenzymes and Myofibrillar Structure.

18 Ellington and Suzuki The CK reaction (phosphocreatine [PCr] + MgADP + H+ ↔ creatine [Cr] + MgATP) fulfills a variety of physiological roles in cells displaying high and variable rates of ATP turnover including (a) temporal and spatial ATP buffering, (b) regulation of glycogenolysis through the sequestration and release of inorganic phosphate and (c) intracellular pH regulation via the liberation of inorganic phosphate, an effective proton buffer, upon net PCr hydrolysis (Ellington, 2001). Much of our understanding of these physiological roles as well as the nature of CK is based on studies of higher animals, mostly mammals and birds.

Biol. Biotechnol. 2: 71–75. , 1990, The phosphorcreatine shuttle of sea urchin sperm: flagellar creatine kinase resulted from a gene triplication. Proc. Natl. Acad. Sci. USA 87: 5203–5207. , 1992, Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism. Biochim. Biophys. Acta 1102: 119–166. , 2000, Creatine and creatinine metabolism. Physiol. Rev. 80: 1107–1213. CHAPTER 3 THE CREATINE KINASE PHOSPHOTRANSFER NETWORK: THERMODYNAMIC AND KINETIC CONSIDERATIONS, THE IMPACT OF THE MITOCHONDRIAL OUTER MEMBRANE AND MODELLING APPROACHES VALDUR SAKS1 2 , TUULI KAAMBRE2 , RITA GUZUN1 , TIIA ANMANN2 , PEETER SIKK2 , UWE SCHLATTNER1 3 , THEO WALLIMANN3 , MAYIS ALIEV4 AND MARKO VENDELIN5 1 Laboratory of Fundamental and Applied Bioenergetics, INSERM U 884, Joseph Fourier University, 2280, Rue de la Piscine, BP53X – 38041, Grenoble Cedex 9, France 2 Laboratory of Bioenergetics, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia 3 Institute of Cell Biology, ETH-Zurich, Hönggerberg HPM D24, Schafmattstrasse 18, CH-8093 Zurich, Switzerland 4 Cardiology Research Center, Institute of Experimental Cardiology, Laboratory of Cardiac Pathology, 121552 Moscow, Russia 5 Department of Mechanics and Applied Mathematics, Institute of Cybernetics, Tallinn Technical University, Akadeemia tee 21, 12618 Tallinn, Estonia Abstract: In this review, we summarize the main structural and functional data on the role of the phosphocreatine (PCr) – creatine kinase (CK) pathway for compartmentalized energy transfer in cardiac cells.

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