Download Conquering RAS. From Biology to Cancer Therapy by Asfar Azmi PDF

By Asfar Azmi

Conquering RAS: From Biology to melanoma Therapy presents introductory wisdom on how smooth RAS biology is taking form in gentle of more moderen technological improvement. each one bankruptcy is written in a way that emphasizes simplicity and clarity for either new investigators and proven researchers. whereas RAS biology has been intensively studied for greater than 3 many years, we're but to determine any powerful therapeutics which may intervene within the signaling cascade regulated through this grasp oncogene.

The e-book covers issues starting from uncomplicated RAS biology, to translational biology and drug discovery functions. those subject matters may be beautiful to simple researchers operating in labs who search deeper knowing of the fashionable suggestions in RAS examine. at the different facet, the oncologist on the patient’s bedside will locate the publication worthy as they frequently face the daunting job of treating sufferers that predominantly have a illness pushed by means of oncogenic KRAS.

  • Brings jointly large ranging subject matters in RAS easy and translational biology for the clinical and medical communities
  • Showcases fresh developments in RAS study lower than one accomplished volume
  • Includes movies, colour illustrations, and critical web site hyperlinks to facilitate a transparent realizing of RAS in melanoma research

Show description

Read Online or Download Conquering RAS. From Biology to Cancer Therapy PDF

Similar molecular biology books

Origin and Evolution of Telomeres

Telomerase: evolution, constitution, and serve as / Marie-Eve Brault, Yasmin D'Souza, and Chantal Autexier -- Drosophila telomeres: a edition at the telomerase topic / Mary-Lou Pardue and P. Gregory DeBaryshe -- substitute lengthening of telomeres in mammalian cells / Anthony J. Cesare and Roger R. Reddel -- T-loops, T-circles, and slippery forks / Sarah A.

Stochastic Transport in Complex Systems: From Molecules to Vehicles

The 1st a part of the e-book presents a pedagogical advent to the physics of complicated structures pushed faraway from equilibrium. during this half we speak about the fundamental innovations and theoretical suggestions that are normal to review classical stochastic shipping in platforms of interacting pushed debris.

Advanced Optical Flow Cytometry: Methods and Disease Diagnoses

A close examine the most recent study in non-invasive in vivo cytometry and its purposes, with specific emphasis on novel biophotonic tools, affliction prognosis, and tracking of ailment remedy at unmarried telephone point in desk bound and circulation stipulations. This e-book hence covers the spectrum starting from primary interactions among mild, cells, vascular tissue, and cellphone labeling debris, to options and possibilities for preclinical and scientific study.

Managing Salt Tolerance in Plants: Molecular and Genomic Perspectives

Salinity tension at the moment affects greater than eighty million hectares of land world wide and extra arable land may be impacted sooner or later as a result of worldwide weather alterations. handling Salt Tolerance in vegetation: Molecular and Genomic views provides special molecular and genomic methods for the improvement of crop crops tolerant to salinity pressure.

Additional info for Conquering RAS. From Biology to Cancer Therapy

Example text

85] Mauviel A, Nallet-Staub F, Varelas X. Integrating developmental signals: a Hippo in the (path) way. Oncogene 2012;31:1743–56. [86] Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007;130:1120–33. [87] Hong X, Nguyen HT, Chen Q, Zhang R, Hagman Z, Voorhoeve PM, et al. Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover. EMBO J 2014;33:2447–57. [88] Xin M, Kim Y, Sutherland LB, Qi X, McAnally J, Schwartz RJ, et al.

Not surprisingly, many scaffolding proteins are also disrupted in cancer cells and lead to an inappropriate level of Ras signaling, such as the RAS-RAF scaffold CNK, the RAF-MEK scaffolds KSR and IQGAP [10,11], MP1, which supports and localizes MEK-ERK [12], and the RASSF1 scaffold, which limits MEK activation [13] (Fig. 1). 1 Scaffolding proteins RASSF, SAV, and MOB are central to the activation of the Hippo pathway. Conversely, additional scaffolds (b-PIX, Ajuba) block the ability of LATS to phosphorylate YAP (red lines) and are positively responsive to JNK or ERK phosphorylation (green arrows).

19] Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, et al. Functions of TAp63 and p53 in restraining the development of metastatic cancer. Oncogene 2014;33:3325–33. [20] Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, et al. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci USA 2010;107:246–51. [21] Oren M, Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol 2010;2:a001107. [22] Irvine KD, Harvey KF.

Download PDF sample

Rated 4.32 of 5 – based on 36 votes