Download Affinity Capillary Electrophoresis in Pharmaceutics and by Reinhard H. H. Neubert, Hans-Hermann Ruttinger PDF

By Reinhard H. H. Neubert, Hans-Hermann Ruttinger

This quantity offers breakthroughs and strategies in affinity capillary electrophoresis to degree and make certain the physicochemical and thermodynamic parameters of drug compounds. It discusses recommendations to discover and symbolize interactions to facilitate advancements in managed drug supply and targeting.

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In this case the traveling time td of the marker relates to the hydrodynamic flow velocity v at the applied pressure: v= ld td © 2003 by Marcel Dekker, Inc. (16) where ld is the length of the capillary from the injection point to the detector. Viscosity is then calculated using the Hagen–Poiseuilles law (5): ␩= ␲ и⌬pиr 4 8иvиl (17) where l is the total length of the capillary. Since only viscosity ratios have to be determined, only the traveling-time ratios have to be considered, provided that all measurements are done with the same capillary at constant pressure.

1 for KA = 105 L/mol. All mobilities are between ␮S and ␮SL . © 2003 by Marcel Dekker, Inc. Fig. 1 Typical binding curve using Eq. (15). Nonlinear regression analysis of a plot of ␮ or Y against [L] provides the association constant KA , and the electrophoretic mobility of the pure complex ␮SL from the experimental data. ␮S corresponds to the substrate mobility at [L] = 0. [L] can be approximated as the added ligand concentration only when the ligand concentration is much greater than the solute concentration or when the binding constant is small.

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