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Extra resources for 100-Area Monthly Reports [for 1947] [declassified]
The potency of oxytocin is still based on a bioassay of avian vasopressive activity, with one United States Pharmacopoeia unit being equivalent to 2 mg of oxytocin. Traditionally, it has been held that oxytocin levels reached a steady-state level within 15 to 20 minutes of beginning an infusion or increasing the dosage. Recent work using a sensitive oxytocin radioimmunoassay has shown that approximately 40 minutes are required for any particular dose of oxytocin to reach a steady-state plasma concentration .
Ultrasound Obstet Gynecol 2002;3:254 – 7. Krammer J, O’Brien WF. Mechanical methods of cervical ripening. Clin Obstet Gynecol 1995;38:280 – 6. Woodman WB. Induction of labor at eight months, and delivery of a living child in less than four hours by Dr. Barnes’s method. Lancet 1863;I:10. Vengalil SR, Guinn DA, Olabi NF, et al. A randomized trial of misoprostol and extraamniotic saline infusion for cervical ripening and labor induction. Obstet Gynecol 1998;91: 774 – 9. Sherman DJ, Frenkel E, Pansky M, et al.
The number of subjects studied affords a power of at least 90% to detect a difference in neonatal intensive care unit admission rates of at least four 192 sanchez-ramos percentage points (ie, from 14% to 18%). 8%). Compared with women who received dinoprostone, Foley catheter, or placebo, women who received misoprostol were twice as likely to experience tachysystole and hyperstimulation, with incidence of these conditions closely related to the dose of misoprostol administered. Although there was increased uterine activity in the misoprostol group, the rate of cesarean deliveries performed for fetal heart rate abnormalities was similar regardless of the induction method used.